LLMs write fluent sentences, but they often miss what humans mean. Tone, intent, sarcasm, hesitation, and cultural signals don’t live in words alone. This whitepaper translates neuroscience and psychology into practical, human-in-the-loop (HITL) workflows that help models read the room, align to brand voice, and respond appropriately in real interactions. You’ll learn how Theory of Mind, mirror neurons, and human pattern processing map to concrete annotation tasks that make perception measurable — and improvable.